The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are sophisticated, necessitating mindful thing to consider of the results on the dad or mum drug, codeine, and the Lively metabolite, morphine.
Discontinuation of a concomitantly employed cytochrome P450 2D6 inhibitor may possibly end in a lower in codeine plasma focus and an increase in Energetic metabolite morphine plasma concentration which could maximize or extend adverse reactions and could result in perhaps fatal respiratory depression.
Never take two doses concurrently or additional doses. Over and over promethazine and codeine is taken on an as desired foundation. Don't take a lot more typically than instructed through the doctor.
Codeine Codeine is definitely an opioid agonist reasonably selective for that mu-opioid receptor, but with a much weaker affinity than morphine. The analgesic and antitussive properties of codeine have already been speculated to come from its conversion to morphine.
The codeine and promethazine in Promethazine with Codeine Oral Solution may improve the frequency of seizures in sufferers with seizure disorders, and should improve the chance of seizures developing in other scientific settings involved with seizures.
Codeine might cause miosis, even in full darkness. Pinpoint pupils are a sign of opioid overdose but aren't pathognomonic (eg, pontine lesions of hemorrhagic or ischemic origin may produce equivalent findings). Marked mydriasis in lieu of miosis might be seen with hypoxia in overdose situations [see
If this SPL consists of inactivated NDCs shown via the FDA initiated compliance motion, They are going to be specified as a result.
Assess Each and every patient's risk ahead of prescribing Promethazine with Codeine Oral Option, prescribe Promethazine with Codeine Oral Resolution for your shortest period that is definitely consistent with unique client remedy goals, observe all sufferers frequently for the event of addition or abuse, and refill only immediately after reevaluation of the necessity for continued treatment. [see Warnings and Safety measures (5.1)]
Opioid analgesics and antitussives, including codeine, one of many Energetic components in Promethazine VC with Codeine Oral Resolution, shouldn't be Employed in patients with acute febrile illness related with productive cough or in individuals with Serious respiratory disease exactly where interference with capacity to clear the tracheobronchial tree of secretions would have a deleterious effect on the affected person’s respiratory perform.
Postmarketing scenarios of respiratory depression, including fatalities, are documented with usage of promethazine in pediatric sufferers. Concomitant administration with other respiratory depressants might enhance the threat of respiratory despair.
Often use an precise milliliter measuring machine when administering Promethazine VC with Codeine Oral Alternative to make sure that the dose is measured and administered precisely. A house teaspoon will not be an precise measuring product and could lead on to overdosage [ see Warnings and Safety measures ( five.7) ]. For prescriptions the place a measuring system will not be furnished, a pharmacist can offer an suitable measuring unit and can provide Directions for measuring the correct dose. Do not overfill.
This merchandise may well comprise inactive substances, which can cause allergic reactions or other issues. Speak to your pharmacist for more particulars.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced.
Unresponsive Cough The dosage of Promethazine VC with Codeine get more info Oral Remedy shouldn't be greater if cough fails to reply; an unresponsive cough should be reevaluated in 5 days or faster for possible underlying pathology, like foreign entire body or decrease respiratory tract disorder [ see Dosage and Administration ( two.three) ].